中国药理学通报2011，Vol.27Issue(8)：1041-1044,4.DOI:10.3969/j.issn.1001-1978.2011.08.002
细胞骨架与神经退行性疾病
Cytoskeleton and neurodegenerative diseases
摘要
Abstract
Neurodegenerative diseases is a kind of chronic progressive neurological disease characterized by neuron degeneration.There have been many theories accounting for this complex disease, including mitochondrial dysfunction, oxidative stress theory, misfolded protein aggregation, inflammation, immune defects, and genetic mutations.In recent years, researches have demonstrated that cytoskeleton played an important role in neuronal degeneration process.Cytoskeleton system determines and maintains cell morphology and it is involved in cell movement, division, cytoplasmic transport and of great significance to other signal transduction.In this review, we discuss recent research progress in neurodegenerative diseases.关键词
细胞骨架/神经元变性/神经退行性疾病/Tau蛋白/微管/中间纤维Key words
cytoskeleton/ neuronal degeneration/ neurodegenerative diseases/ Tau protein/ microtubules/ intermediate filaments分类
医药卫生引用本文复制引用
张蕊,苑玉和,赵明,陈乃宏..细胞骨架与神经退行性疾病[J].中国药理学通报,2011,27(8):1041-1044,4.基金项目
国家创新药物重大专项资助项目(No 2008ZX09101,2009ZX09303,2009ZX09301,2009ZX09303) （No 2008ZX09101,2009ZX09303,2009ZX09301,2009ZX09303）
国家自然科学基金资助项目(No 30973887,81073078,81073130) （No 30973887,81073078,81073130）
国家自然科学基金广东省自然科学联合基金资助项目(No U0832008) （No U0832008）
