中国药理学通报2011，Vol.27Issue(8)：1064-1067,4.DOI:10.3969/j.issn.1001-1978.2011.08.008
摄食海参皂苷对小鼠高尿酸血症的影响
The effect of dietary sea cucumber saponin on hyperuricemia in mice
摘要
Abstract
Aim To investigate the effect of sea cucumber saponin ( SSC ) on uric acid metabolism in yeast extract powder induced hyperuricemia mice.Methods Thirty Kunming mice were divided into normal group, model group, SSC low dosage group ( 0. 05％ SSC ), SSC high dosage group( 0.1％ SSC )and non-saponin sea cucumber residue group (residue ). Hyperuricemic models were made by orally administering yeast extract powder for 14 days. The concentration of serum uric acid ( UA ), creatinine ( Cr ),blood urea nitrogen ( BUN ) and the activity of liver xanthine oxidase (XOD) and adenosine deaminase ( ADA ) were determined. Results After 14 days, the 0.05％ SSC and 0.1％ SSC decreased serum uric acid level by 53.1％ ( P ＜0.01 ) and 55.6％ ( P ＜0.01 )respectively. Hepatic XOD and ADA activities were reduced significantly by SSC treatment. Dietary 0.05％SSC and 0. 1％ SSC treatment reduced XOD activity by 26.3％ ( P ＜0.01 ) and 28.6％ ( P ＜0.01 ) respectively, and reduced ADA activity by 24.4％ ( P ＜0.05 ) and 34.0％ ( P ＜ 0.01 ) respectively. However, the serum Cr and BUN levels were similar between the model and SSC treatment groups. Conclusions SSC possesses a potent anti-hyperuricemic effect on yeast extract powder induced hyperuricemia, and the mechanism is relevant in decreasing the activity of liver XOD and ADA.关键词
海参/皂苷/高尿酸血症/尿酸/黄嘌呤氧化酶/腺苷脱氨酶Key words
sea cucumber/ saponin/ hyperuricemia/ uric acid/ xanthine oxidase/ adenosine deaminase分类
医药卫生引用本文复制引用
徐慧静,张灏,刘春花,薛勇,薛长湖,王玉明..摄食海参皂苷对小鼠高尿酸血症的影响[J].中国药理学通报,2011,27(8):1064-1067,4.基金项目
国家自然科学基金资助项目(No 30972285) （No 30972285）
国际科技合作项目(No 2010DFA31330) （No 2010DFA31330）
