广东医学2011，Vol.32Issue(13)：1652-1654,3.
甘珀酸钠苦参素包合物对大鼠实验性肾炎的影响
Effects of oxymatrine-carbenoxolone sodium complex on bovine serum albumin-induced nephritis in rats
摘要
Abstract
Objective To study the effects of oxymatrine - carbenoxolone sodium complex ( OCSIC ) on bovine serum albumin - induced nephritis in rats. Methods Rat nephritis model was estahlished by intravenous injection of bovine serum albumin. OCSIC treatment was given for 5 weeks. During treatment, general status was observed. and weight and 24 h urinary protein excretion were recorded each week. Heart blood was attained for detection of serum levels of Ucr,BUN, IL - 1β , IL - 6 and TNF - α under anesthesia after treatment. Results COCIS significantly reduced the 24 h urinary protein excretion and serum levels of Ucr, BUN, IL - 1 β , IL - 6 and TNF - α. Pathological study revealed alleviated renal injury and inflammatory infiltration. Conclusion Significant efficacy of OCSIC on hovine serum albumin - induced nephritis is proved in rats.关键词
甘珀酸钠苦参素包合物/大鼠/实验性肾炎Key words
oxvmatrine - carbenoxolone sodium complex/ rat/ experimental nephritis引用本文复制引用
黄伟,丁建伶,肖旭,任广慧,姚青..甘珀酸钠苦参素包合物对大鼠实验性肾炎的影响[J].广东医学,2011,32(13):1652-1654,3.基金项目
宁夏回族自治区科技攻关项目(编号:宁科计字[2009]139号) （编号:宁科计字[2009]139号）
