广东牙病防治2011，Vol.19Issue(5)：249-253,5.
维生素D受体基因Tag I和Bsm I位点单核苷酸多态性与种植体周围炎的易感性研究
Association of Peri-implantitis with Vitamin D Receptor Gene Polymorphism (Tagi, BsmI)
刘琼 1黄建生 1徐平平 1刘天涛 1戚娟娟 1黄晓虹 1刘丹1
作者信息
- 1. 南方医科大学附属口腔医院·广东省口腔医院特诊中心,广东,广州,510280
- 折叠
摘要
Abstract
Objective To investigate the association between vitamin D receptor polymorphism (Tagl, Bsml) and peri-implantitis. Methods The genotype and allele distributions of vitamin D receptor in a case-control study involving 50 patients with peri-implantitis ( M group) and 50 health controls ( N group) were analyzed by PCR-restriction fragment length polymorphism. Results A different distribution (P ＜ 0.05 ) of Taql VDR genotypes was found in M group compared with N group, but not Bsml VDR. In particular, the prevalence of TT VDR genotypes in M group was significantly higher than in N group. Conclusion Excluded some influence factors, such as smoking and periodontitis, the results demonstrateds that a genetic association of peri-implantitis with Taql VDR polymorphism and, but not with Bsml VDR.关键词
种植体周围炎/维生素D受体/基因多态性Key words
Peri-implantitis/ Vitamin D receptor/ Gene polymorphism分类
医药卫生引用本文复制引用
刘琼,黄建生,徐平平,刘天涛,戚娟娟,黄晓虹,刘丹..维生素D受体基因Tag I和Bsm I位点单核苷酸多态性与种植体周围炎的易感性研究[J].广东牙病防治,2011,19(5):249-253,5.
