广东牙病防治2011，Vol.19Issue(5)：253-256,4.
氟康唑对HIV感染者口腔白色念珠菌抗真菌后效应的体外研究
In vitro Post-antifungal Effect of Fluconazole against Oral Candida Albicans Isolates in HIV Disease
摘要
Abstract
Objective To evaluate the minimum inhibitory concentration (MIC) and measure post-antifungal effect (PAFE) of oral Candida albicans isolates following limited exposure to fluconazole. Methods Ten oral isolates of C. albicans were examined for the presence of the PAFE following limited exposure to fluconazole (4 × MIC and 6 × MIC), respectively, measured using automated turbidometry. Results The duration of the mean PAFE for C. albican ATCC 90031 induced by fluconazole at concentrations of 4 × MIC and 6 × MIC in RPMI medium were 0. 12 h and 3.14 h respectively, compared with (0.19 ± 0. 24) h and ( 2.08 ± 0.25 ) h respectively, for all 10 isolates of C. albicans. Significant intra-strain differences in PAFE were observed after exposure to 6 × MIC fluconazole ( P = 0. 000 ), but not for 4 × MIC fluconazole (P = 0. 529). Conclusion Fluconazole can effectively perturb C. albicans growth and elicited a peired of PAFE in C. albicans.关键词
氟康唑/抗真菌后效应/白色念珠菌Key words
Fluconazole/ Post antifungal effect/ Candida albicans分类
医药卫生引用本文复制引用
陆晓璐,徐平平,罗刚,杨梅,董俊英,张里君,王雅静,柯昌文..氟康唑对HIV感染者口腔白色念珠菌抗真菌后效应的体外研究[J].广东牙病防治,2011,19(5):253-256,4.基金项目
广东省医学科学技术研究基金(B2007025,A2008109) （B2007025,A2008109）
