中国药房2011，Vol.22Issue(22)：2072-2074,3.
替莫唑胺联合放疗在非小细胞肺癌脑转移中的临床研究
Clinical Research of Temozolomide Combined with Radiotherapy in the Treatment of Brain Metastasis in Patients with Non-small Cell Lung Cancer
周蕾 1安广宇 1岳振东 1陈力 1宋雨光 1姜妮1
作者信息
摘要
Abstract
OBJECTIVE: To investigate the therapeutic efficacy and safety of temozolomide combined with radiotherapy in the treatment of brain metastasis in patients with non-small cell lung cancer and its effect on overall survival time.METHODS: 42 brain metastases patients with non-small cell lung cancer were randomized into temozolomide combined with radiotherapy group and radiotherapy group: Temozolomide combined with radiotherapy group was given temozolomide 75 mg·m-2·d-1 and conventional head radiotherapy of a total dose of 40 Gy fractionated (2 Gy, 5 d/week) for 4 weeks while radiotherapy group was given radiotherapy of a total dose of 40 Gy alone.Temozolomide combined with radiotherapy group received temozolomide therapy (first cycle: 150 mg·m-2·d-1;second to the sixth cycles:200 mg·m-2·d-1) for 5 days every 28 days for an additional six cycles.RESULTS: The objective response rates of temozolomide combined with radiotherapy group and radiotherapy group were 75％ and 64％ (P=0.017), there was significant difference.The incidence rates of neutropenia in two groups were 40％ and 27％ (P=0.019), those of thrombocytopenia was 10％ and 5％ (P=0.045) and those of hemochrome decreasing were 25％ and 18％ (P=0.024), respectively.There were significant differences.Overall survival time of two groups were 9.2 and 7.9, there was no significant difference (P=0.449).CONCLUSION: Temozolomide combined with radiotherapy is safe and effective in the treatment of brain metastasis in patients with non-small cell lung cancer.关键词
替莫唑胺/非小细胞肺癌/脑转移癌Key words
Temozolomide/ Non-small cell lung cancer/ Brain metastasis cancer分类
医药卫生引用本文复制引用
周蕾,安广宇,岳振东,陈力,宋雨光,姜妮..替莫唑胺联合放疗在非小细胞肺癌脑转移中的临床研究[J].中国药房,2011,22(22):2072-2074,3.
