中国药房2011，Vol.22Issue(23)：2122-2124,3.
制何首乌单用或伍用白蒺藜对小鼠肝脏毒性的比较研究
Comparative Study on Hepatotoxicity of Polygoni Multiflori Radix Praeparata and Tribulus terrestris Alone or in Combination on Mice
摘要
Abstract
OBJECTIVE: To study on hepatotoxicity of Polygoni Multiflori Radix Praeparata and Tructus terrestris alone or in combination on mice. METHODS: High-dose and low-dose groups were set up. The hepatotoxicity of Polygoni Multiflori Radix Praeparata and T. terrestris alone or in combination on mice was evaluated at the end of 6th week, 2 week after stopping drug withdrawal and at the end of 8th week. RESULTS: No matter what high or low dose Polygoni Multiflori Radix Praeparata and T. terrestris alone or in combination, the liver enzymes and the liver index both had no significant difference. However, pathomorphological observation suggested there were changes in different stages. The pathomorphological change was probably proportional to the amount and period of dose. CONCLUSION: Polygoni Multiflori Radix Praeparata and T. terrestris alone or in combination have no evident influence on liver enzymes of mice with experimental dose and period, but long-term high dose usage should be avoided to prevent possible damnification.关键词
制何首乌/白蒺藜/肝毒性Key words
Polygoni Multiflori Radix Praeparata/ Tructus terrestris/ Hepatotoxicity分类
医药卫生引用本文复制引用
夏蕾,王丽霞,牟稷征..制何首乌单用或伍用白蒺藜对小鼠肝脏毒性的比较研究[J].中国药房,2011,22(23):2122-2124,3.基金项目
中国中医科学院广安门医院科研基金课题(2007S137) （2007S137）
