中国医科大学学报2011，Vol.40Issue(5)：400-404,5.DOI:CNKI:21-1227/R.20110523.1816.028
交感能受体阻断剂和去肾神经对5/6肾切除大鼠的肾脏保护作用
The Renoprotective Actions of Sympathetic Blocking Agent and Renal Denervation in the Rat Renal Ablation Model
摘要
Abstract
Objective To disscuss the renoprotective actions of the sympathetic blocking agent and renal denervation in the rat renal ablation model. Methods 40 wistar rats were randomly devided into 4 groups. The first group served as negative control by sham operating.The second one as positive control by 5/6 subtotal nephrectomy (SNX) .The third one was underwent SNX, The fourth group underwent SNX and resection of dorsal roots,i.e. rhizotomy. The negative control,the positive control group and the fourth group were administrated tap water,the third group was given sympathetic blocking agent for 8 weeks. Results At the end of the study,the blood pressure of the rats was 118.67±13.34 mmHg in the negative control group, 173.49±16.48 mmHg in the positive control group,ll5.67±15.53 mmHg in the third group and 107.99±12.35 mmHg in the fourth group,respectively. Albuminuria was 6.19±2.70,35.35±4.58,16.49±3.77,14.23±0.69 mg/24 h,respectively. The glomerulosclerosis of the third and fourth group were better than that of the others. The lowest indices for collagen Ⅲ, collagen V and AT1-R were found in the third and fourth group. (P ＜ 0.05). Conclusion The sympathetic blocking agent and renal denervation can protect the remanent kidney injury.关键词
慢性肾脏病/交感能受体阻断剂/5/6肾切除模型/去肾神经Key words
chronic kidney disease/ sympathetic blocking agent/ 5/6 subtotal nephrectomy/ renal denervation分类
医药卫生引用本文复制引用
闵睿,王宗谦,陈望,赵欣欣,李艳浓,丁红..交感能受体阻断剂和去肾神经对5/6肾切除大鼠的肾脏保护作用[J].中国医科大学学报,2011,40(5):400-404,5.基金项目
辽宁省教育厅高校科研计划(2008845) （2008845）
