首页|期刊导航|中华医学杂志（英文版）|HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na(i)ve to antiretroviral therapy
HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na(i)ve to antiretroviral therapy
XIAO Jian LI Ming-yuan WANG Ying QIAN Ke-lei CAO Qing-hua QIU Chen-li QIU Cao XUE Yi-le ZHANG Xiao-yan ZHONG Ping XU Jian-qing
中华医学杂志（英文版）2011，Vol.124Issue(15)：2340-2346,7.
中华医学杂志（英文版）2011，Vol.124Issue(15)：2340-2346,7.DOI:10.3760/cma.j.issn.0366-6999.2011.15.017
HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na(i)ve to antiretroviral therapy
HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na(i)ve to antiretroviral therapy
摘要
Abstract
Background The frequencies of regulatory T cells (Tregs) increased over the HIV infection but its counts actually decreased. We proposed that the decrease of Treg counts may cause the reduction of inhibitory effect and thereby account for the over-activation of Tregs during HIV infection. However, it remains unknown whether Tregs are also over-activated and thereafter the activation induced death may lead to the decrease of Tregs. Methods Tregs were defined as CD4+CD25+CD127lo/-T cells. Eighty-one HIV-1 infected patients were enrolled in our study, and twenty-two HIV-1 seronegative donors were recruited as the control. The levels of HLA-DR on Tregs were determined by FACSAria flow cytometer. ResultsCompared to HIV-1 seronegative donors, the levels of HLA-DR on CD4+CD25+CD127lo/- Tregs were significantly increased in HIV-1 infected patients, and its increase was positively associated with viral loads (r=0.3163,P=0.004) and negatively with CD4 T-cell counts (r=-0.4153, P<0.0001). In addition, significant associations between HLA-DR expression on CD4+CD25+CD127lo/-Tregs and the percentages of HLA-DR, CD38, Ki67 expressing CD4+ and CD8+ T cells were also identified. Conclusion HLA-DR on Tregs is a good marker for viral replication and disease progression. The over-activation of Tregs might result in the decrease of Tregs.关键词
human immunodeficiency virus type 1/T-lymphocytes, regulatory/HLA-DR antigens/immune activationKey words
human immunodeficiency virus type 1/T-lymphocytes, regulatory/HLA-DR antigens/immune activation引用本文复制引用
XIAO Jian,LI Ming-yuan,WANG Ying,QIAN Ke-lei,CAO Qing-hua,QIU Chen-li,QIU Cao,XUE Yi-le,ZHANG Xiao-yan,ZHONG Ping,XU Jian-qing..HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na(i)ve to antiretroviral therapy[J].中华医学杂志（英文版）,2011,124(15):2340-2346,7.基金项目
This study was supported by the grants from the National Foundation of China (No.30872256),the National Grand Program on Key Infectious Disease Control from Ministry of Sciences and Technology and Ministry of Health (No.2008ZX 10001-002).Conflicts of interest:none. （No.30872256）
