中国实用儿科杂志2011，Vol.26Issue(6)：443-445,449,4.
胱抑素C联合尿微量蛋白和肌酐检测诊断儿童过敏性紫癜早期肾损害临床价值研究
The value of cystatin C and urine protein/creatinine ratio detection in predicting early renal damage of children with Henoch-Sch(o)nlein purpura
王峥艳 1单春明 1徐君华2
作者信息
- 1. 江苏省淮安市第二人民医院,儿科,江苏淮安,223002
- 2. 江苏省淮安市第二人民医院,肾脏病实验室,江苏淮安,223002
- 折叠
摘要
Abstract
Objective To evaluate the value of combined detection of serum cystatin C (Cys C) and urine protein series in predicting renal damage of childhood Henoch-Sch(O)nlein purpura (HSP). Methods Serum Cys C and urine protein series were tested in 46 child HSP patients, using liquid transmission turbidity and immune nephelometry. Urine protein series included transferrin (TRF), NAG/UCr, IGGU/UCr, ALBU/UCr and α 1MU/UCr. Meanwhile, serum creatinine,urine and serum urea nitrogen were determined. The results were compared with those of healthy control group. Results The value of serum Cys C and urine protein series in HSP patients were higher than those of control group (4.28 ± 0.36) mg/L vs (0.65 ± 0.43) mg/L for serum Cys C(P ＜ 0.01 ) ;80.43％(37/46) HSP patients whose routine urinalysis were negative had abnormal tested value of six indexes in complete blood test and urine analysis. The value of serum Cys C had a positive correlation with urine protein series. Conclusion Six indexes in complete blood test and urine analysis including serum Cys C and urine protein series help to reveal early renal damage in HSP patients, whilst negative urinalysis can' t rule out early renal damage. The sensitivity and specificity of serum Cys C are superior to urine protein series. These six indexes are appropriate indicators in diagnosis of early renal injury in childhood HSP patients.关键词
胱抑素C/尿微量蛋白/肌酐比值/儿童/过敏性紫癜/早期肾损害Key words
cystatin C/ urine protein/creatinine ratio/ children/ Henoch-Sch(O)nlein purpura/ early renal damage分类
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王峥艳,单春明,徐君华..胱抑素C联合尿微量蛋白和肌酐检测诊断儿童过敏性紫癜早期肾损害临床价值研究[J].中国实用儿科杂志,2011,26(6):443-445,449,4.
