中国实用儿科杂志2011，Vol.26Issue(6)：450-453,4.
重型β地中海贫血铁过载患儿心脏与肝脏磁共振T2*检测及其相关因素分析
Detection of myocardial T2* and liver T2* in β-thalassemia major patients with iron overload and the analysis of related factors
摘要
Abstract
Objective To study the status of myocardial T2* and liver T2* in β - thalassemia major( β -TM) patients with iron overload and its relationship with clinical tesl data.Methods In Jnne 2010, on a voluntary basis, out of the 80 β-TM patients over 7 years under regular blood transfusion therapy, 51 were chosen to receive myocardial MRI T2* (myocardial T2* ) and liver MRI T2* (liver T2*) tests.The results were compared with age, SF, LVEF, transfusion time,chelation time and Hb.Results Eleven out of 51 cases (21.6％) were myocardial iron overload, including 3 mild cases,3 moderate cases and 5 severe cases.Forty-three out of 51 cases ( 84.3％ ) were liver iron overload, including 14 mild cases, 17 moderate cases and 12 severe cases.There was no correlation between myocardial T2* and SF, LVEF or liver T2*.SF was positively correlated with liver T2* (r = 0.558, P ＜ 0.01 ).The transfusion time of myocardial T2* ＞ 20 ms group was less than that of myocardial T2* ＜ 20 ms group (P ＜ 0.05).There was no statistical significance between the liver iron overload incidence ratios of the two groups ( P ＞ 0.05 ).Two out of 11 myocardial iron overload cases had lower LVEF (18.2％).Conclusion The group of TM patients demonstrates lower myocardial iron overload incidence and higher liver iron overload incidence.As SF increases, liver iron overload becomes more severe; myocardial iron overload can not be predicted or determined by examining SF level.There is no correlation between myocardial iron overload and liver iron overload.LVEF can not be a reliable factor to predict myocardial iron overload.关键词
β-地中海贫血,重型/心肌铁过载/心脏磁共振/血清铁蛋白/左室射血分数Key words
β- thalassemia major/ myocardial iron overload/ cardiac magnetic resonance imaging/ serum ferritin/ left ventricular ejection fraction分类
医药卫生引用本文复制引用
高红英,陈光福,陈娟娟..重型β地中海贫血铁过载患儿心脏与肝脏磁共振T2*检测及其相关因素分析[J].中国实用儿科杂志,2011,26(6):450-453,4.基金项目
深圳市科技计划项目(No.200903051) （No.200903051）
