山东医药2011，Vol.51Issue(24)：33-35,3.
广西肺鳞状细胞癌RASSF1A及RPRM基因甲基化分析
Analysis of RASSF1A and RPRM gene methylation in Guangxi lung squamous cell carcinoma
摘要
Abstract
Objective To analysis RASSF1A and RPRM gene methylation in Guangxi patients with lung squamous cell carcinoma. Method Methylation specific polymerase chain reaction (MSP) was used to detect RASSF1A and RPRM gene methylation state in 30 Guangxi patients with lung squamous cell carcinoma and 10 patients with benign lung diseases (control group). Result Gene methylation rate of RASSF1A and RPRM in lung squamous cell carcinoma patients was 83.3％ (25/30) and 70.0％ (21/30), 0 and 10％ (2/20) in control group respectively (P ＜0.01 ). Conclusion RASSF1A and RPRM gene methylation detection maybe helpful to diagnose lung squamous cell carcinoma.关键词
癌,鳞状细胞/RASSF1A/RPRM/DNA甲基化Key words
carcinoma, squamous cell/ RASSF1A/ RPRM/ DNA methylation分类
医药卫生引用本文复制引用
冯旭,覃家锦,周华富,郑宝石,何巍..广西肺鳞状细胞癌RASSF1A及RPRM基因甲基化分析[J].山东医药,2011,51(24):33-35,3.基金项目
广西壮族自治区卫生厅课题(Z2008099) （Z2008099）
