山东医药2011，Vol.51Issue(24)：39-41,3.
缬沙坦对野百合碱诱导肺动脉高压模型大鼠血浆CRP、ET-1和NO水平的影响
Effects of valsartan on the plasma CRP, ET-1 and NO levels in pulmonary hypertensive rat models induced by monocrotaline
摘要
Abstract
Objective To observe the changes of c-reactive protein (CRP), endothlin (ET) and nitric oxide (NO)in pulmonary hypertensive rats induced by monocrotaline after valsartan interventions. Methods The healthy Wistar rats were injected with 60 mg/kg of monocrotaline, after 4 weeks, the models were reproduced. The intervention group was treated with 20 mg/( kg · d) of valsartan intragastrically for 4 weeks. The parameters of pulmonary hemodynamics were monitored, the levels of CRP, ET-1 and NO were detected. Result The levels of the mean pulmonary arterial pressure, CRP,ET-1 were declined and the level of NO was increased after valsartan interventions (P ＜ 0.05 ). Conclusion Valsartan can decrease the mPAP and ameliorate the levels of CRP, ET-l/NO in pulmonary hypertensive rats, the mechanism maybe related with its effects of protecting endothelial cells.关键词
缬沙坦/野百合碱/高血压,肺性/C反应蛋白质/内皮素/一氧化氮Key words
valsartan/ monocrotaline/ hypertension, pulmonary/ c-reactive protein/ endothlin/ nitric oxide分类
医药卫生引用本文复制引用
文宏,李醒三,曾晓聪..缬沙坦对野百合碱诱导肺动脉高压模型大鼠血浆CRP、ET-1和NO水平的影响[J].山东医药,2011,51(24):39-41,3.基金项目
广西科技厅科学基金资助项目(桂科基0575069). （桂科基0575069）
