中国药业2011，Vol.20Issue(15)：8-10,3.
氧化苦参碱胶束纳米粒制备及其体外抗肿瘤活性研究
Preparation and in Vitro Antitumor Effect of Oxymatrine Micellar Nanoparticles
摘要
Abstract
Objective A novel oxymatrine (OMT) micellar nanoparticles,which has ability to delay release of the drug and meanwhile to enhanre cytotoxicity against the cancer cells is anticipated to investigate in this study. Methods The better one between co - solvent evaporation method and high frequency ultrasound probe method is sifted to prepare the micellar nanoparticles for OMT,which would be evaluated its physical and release characteristics,cytotoxic activity in vitro and the stability. Results Though its stability remains to be improved,LP22-the hest choice in this preparation process by co - solvent evaporation method - releases was slower than free OMT and its anit - SMMC -7721 effect in vitro in a low concentration was stronger than OMT aqueous solution. Conclusion LP22 has certain sustained release effect and antiturnor effect in vitro as well as the potential to enhance tumor of liver accumulation.关键词
氧化苦参碱/胶束纳米粒/抗肿瘤/缓释/靶向Key words
oxymatrine/ micellar nanoparticles/ antitumor effect/ sustained - release/ targetting分类
化学化工引用本文复制引用
金楠,赵永星,孙倩,刘敏,邓书华..氧化苦参碱胶束纳米粒制备及其体外抗肿瘤活性研究[J].中国药业,2011,20(15):8-10,3.基金项目
郑州大学国家大学生创新实验计划项目,项目编号:091045911. （）
