中国药业2011，Vol.20Issue(15)：12-13,2.
T-2毒素对体外培养兔软骨细胞增殖活性的影响
The Effect of T-2 Toxin on Proliferation in Rabbit Chondrocyte
刘斌 1陈德才1
作者信息
- 1. 四川省内江市第一人民医院,四川,内江,641000
- 折叠
摘要
Abstract
Objective To obserwe the effect of trichothecene mycotoxin (T- 2 toxin),a possible pathogenic factor of Kashin- Beck disease (KBD) ,on proliferation of Zelanian rabbits' chondrocyte in itro. Metbods Rabbit chondrocytes cultured in vitro were treated with T- 2 toxin at different concentrations (0,1,10,20,100 μg/L) for 5 d. Cell viability was measured by methyl thiazolyl tetrazolium assay everyday.Results Dose/time- dependent effect of T- 2 toxin was found in chondrocyte viability within a certain range of concentration (1 -100 μg/L) from the first to fifth day. The inhibitory effect of T-2 toxin on chondrocytes was up to maximum on the fifth day. Conclusion T- 2 toxin inhibitted the growth of rabbit chondrocytes and maybe the key role in pathogenesis of Kashin- Beck disease.关键词
大骨节病/软骨细胞/T-2毒素Key words
Kashin - Beck disease/ chondrocyte/ T - 2 toxin分类
医药卫生引用本文复制引用
刘斌,陈德才..T-2毒素对体外培养兔软骨细胞增殖活性的影响[J].中国药业,2011,20(15):12-13,2.
