昆明医学院学报2011，Vol.32Issue(5)：50-53,4.
辅助生殖技术治疗后孕早期自然流产的绒毛细胞染色体分析
Chromosomal Analysis in Spontaneous Abortion during the First Trimester after Assisted Reproduction Technique Treatment
李跃萍 1徐雯 1黎明红 1麦扬青 1陈竞茜 1闫庆峰2
作者信息
- 1. 海南医学院附属医院生殖医学科,海南,海口,570102
- 2. 海南医学院附属医院外科,海南,海口,570102
- 折叠
摘要
Abstract
Objective To know about chromosome abnormalities in spontaneous abortion during the first trimester after assisted reproduction technique treatment and to provide some data for eugenics. Methods A retrospective analysis was performed on 41 clinical spontaneous abortion cases during the first trimester following ART, which including in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI) and frozen embryo transfer (F-ET) and intrauterine insemination (IUI). Cytogenetic analysis of the chorionic villi by cell culture and standard G-banding cytogenetic techniques was performed. Results Successful analysis was conducted in 30 specimens. Fifteen of 30 specimens had a chromosomal abnormality,accounting for 50％. The majorities were numerical abnormalities such as monosomy X (one case). Trisomies for chromosomes 11 cases, including 18 trisomies in one case, 16 trisomies in three cases, 15 trisomies in two case, 4 trisomies in one cases, 9 trisomies in one case, 2 trisomies in one case, mosaic trisomy 21 trisomies in two cases, and polyploidin one case were observed. 46, XX/47, XX, +mar karyotype was observed in one case. Conclusions ART abortion is closely related with embryo chromosome abnormalities. Aneuploidy is the major factor affecting embryonic development in spontaneous abortions during the first trimester after ART.关键词
辅助生殖技术/孕早期/自然流产Key words
Assisted reproduction technique/ First trimester/ Spontaneous abortion分类
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李跃萍,徐雯,黎明红,麦扬青,陈竞茜,闫庆峰..辅助生殖技术治疗后孕早期自然流产的绒毛细胞染色体分析[J].昆明医学院学报,2011,32(5):50-53,4.
