北京大学学报（医学版）2011，Vol.43Issue(3)：379-385,7.DOI:10.3969/j.issn.1671-167X.2011.03.014
基于农村社区人群的心血管危险因素相对效应和性别差异的分层研究
Gender-specific differences in relative effects of cardiovascular risk factors among rural population
摘要
Abstract
Objective : To investigate the prevalence and association of cardiovascular disease and its risk factors in Fangshan District, Beijing. Methods : A total of 7 577 rural residents aged over 40 years were surveyed to estimate the prevalence of cardiovascular disease and its risk factors by questionnaire survey, physical examination and biochemical measures. The prevalence odds ratio ( POR ) was calculated for the association of stroke / coronary heart disease ( CHD) with its risk factors in multiple logistic regression models. Results: Prevalence of CHD, stroke, diabetes, hypertension, dyslipidemia, overweightand obesity was presented as 6.5％ , 4. 1％ , 10.7％ , 39.5％ , 56. 7％ , 44. 0％ and 13. 6％ , respectively. In the adjusted multiple logistic regression models, hypertension showed stronger association with stroke ( POR =2. 780 , 95％ CI: 2. 146 - 3. 602) , while diabetes had a higher correlation with CHD ( POR = 2. 671 , 95％ CI: 2. 121 - 3. 363 ). After stratification by gender, significant risk factors for stroke were overweight / obesity ( POR = 1. 652 , 95％ CI: 1. 122 -2. 433) , body mass index ( POR = 1. 048 , 95％ CI: 1. 002 - 1. 096) , systolic blood pressure ( POR = 1. 017 , 95％ CI: 1. 005 - 1. 030) and serum glucose ( POR = 1. 093 , 95％ CI: 1. 048 - 1. 140) in females , whereas dyslipidemia ( POR = 1. 615 , 95％ CI: 1. 124 - 2. 319) , total cholesterol ( POR = 3. 932. 95％ CI: 1. 533 - 10. 086 ) and high-density lipoprotein cholesterol ( POR = 0. 072 , 95％ CI: 0. 022 - 0. 236) were associated with stroke in males. Conclusion: Highly prevalent cardiovascular risk factors aggravated the burden brought by stroke and CHD in the rural population, and the various risk factors for stroke and CHD exhibited heterogeneous contributions among the population with different gender.关键词
脑卒中/冠状动脉疾病/危险因素/农村人口Key words
Stroke/ Coronary disease / Risk factors/ Rural population分类
医药卫生引用本文复制引用
唐迅,刘武军,温苏申,窦会东,胡永华,何柳,曹洋,王晋伟,李娜,田君,刘建江,于立平,许海涛..基于农村社区人群的心血管危险因素相对效应和性别差异的分层研究[J].北京大学学报（医学版）,2011,43(3):379-385,7.基金项目
国家自然科学基金(30671807,30872173)和国家重点基础研究发展计划(973计划,2006CB503903)资助 （30671807,30872173）
