北京大学学报（医学版）2011，Vol.43Issue(3)：427-431,5.DOI:10.3969/j.issn.1671-167X.2011.03.022
高脂血症患者不同血脂异常分型与糖代谢的相关性研究
Correlation study on different dyslipidemia classification and glucose metabolism in patients with hyperlipidemia
摘要
Abstract
Objective :To detect the impaired glucose metabolism in dyslipidemic patients and explore whether the type of dyslipidemia affects the type of impaired glucose metabolism. Methods: In our study , 197 patients without diabetes or cardiovascular disease history were divided into 4 groups according to fasting serum lipid levels : hypercholesterolemic group ( HCh group , 45 patients) ; hypertriglyceridemic group ( HTG group, 46 patients) ; combined dyslipidemic group (58 patients) and control group (48 patients). Serum insulin and glucose levels were detected in fasting situation. HOMA-IR was calculated. And then the patients received 75 g oral glucose tolerance test ( OGTT) and their GLU120 levels were detected. Results : The GLU120levels in HTG group [ (10.5 ±3.2) mmol/L] and combined dyslipidemic group [ (12.0 ±5. 4) mmol/L] were significantly higher than those in control group [ (8. 7 ± 3. 5) mmol/L, P =0. 045 and 0. 024 , respectively] . HTG group ( 39. 1％ ) and combined dyslipidemic group (31.0％ ) also had higher impaired glucose tolerance (IGT) incidence ratios than those in control group ( 22. 9％ , P = 0. 009 and 0. 014 , respectively) . In subgroup study of patients with fasting glucose levels below 6. 1 mmol/L, the incidence ratios of IGT in HTG group and combined dyslipidemic group were 51. 4％ and 43. 9％ , respectively , which were significantly higher than those in control group ( 29. 7％ , P = 0. 009 and 0. 015 , respectively) . Conclusion : There exists a definite ratio of undiscovered impaired glucose metabolism in dyslipidemic patients who have not suffered from cardiovascular disease , especially in hypertriglyceridemic and combined dyslipidemic group. OGTT is suggested to be brought into effect in order that impaired glucose metabolism would be detected in earlier stage.关键词
高脂血症/葡糖耐量试验/糖尿病Key words
Hyperlipidemia/ Glucose tolerance test/ Diabetes mellitus分类
医药卫生引用本文复制引用
王岚,卢明瑜,任景怡,陈红..高脂血症患者不同血脂异常分型与糖代谢的相关性研究[J].北京大学学报（医学版）,2011,43(3):427-431,5.基金项目
中国医学会心脑血管疾病血糖管理协作组基金项目(08010013)资助 （08010013）
