北京大学学报（医学版）2011，Vol.43Issue(3)：432-435,4.DOI:10.3969/j.issn.1671-167X.2011.03.023
结直肠腺瘤与患者血脂代谢水平
Characteristic analysis of plasma lipid metabolism level in patients with colorectal adenoma
李传凤 1李军 1白鹏 1吕愈敏1
作者信息
- 1. 北京大学第三医院消化科,北京100191
- 折叠
摘要
Abstract
Objective :To evaluate the relationship between serum lipid level and colorectal adenoma.Methods :A review analysis was carried out of the patients who underwent colonoscopy in Peking Univer sity Third Hospital from May 2009 to February 2010. Subjects with history of colorectal adenocarcinoma before colorectal surgery or of medication which had influenced the serum lipid level were excluded. Ade noma group included the patients who had colorectal adenoma which was evidenced by pathology. The patients with no adenoma were ascribed to control group. The serum total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol levels of the two groups were analyzed. The relation between serum lipid level and location of colorectal adenoma was also summarized. Results: A total of 227 patients were included for final analysis, of whom 124 were in adenoma group (77 males and 47 females; mean age:56.5 ± 10.7 years )and 103 in control group(53 males and 50 females; mean age: 56.8 ± 13.6 years).Serum triglyceride level in adenoma group [ ( 1.83 ± 1.04) mmol/L ] was significantly higher than that of control group [ ( 1.54 ± 0.86) mmol/L (P= 0. 022) ] and HDL-C level in adenoma group [ ( 1.05 ±0.32) mmol / L ] was significantly lower than that of control group [ ( 1.26 ± 0.46 ) mmol/L ( P =0. 000) ]. In adenoma group, 73 cases were with HDL-C decreased, which was significantly higher than that of control group (44 cases, P= 0. 015). In addition, higher incidence of proximal colonic adenomas was observed in elevated triglycerides group and low HDL-C group (39.8％, 37.4％ ), compared with control group (25.5％), but there was no statistical difference between the two groups(P = 0. 358).Conclusion: The findings of this study suggest that dyslipidemia may affect the incidence of colorectal adenoma, particularly hypertriglyceridemia and low HDL-C levels. In addition, higher triglyceride and lower HDL-C levels seem to be related to higher incidence of proximal colonic adenomas.关键词
结直肠肿瘤/腺瘤/高脂血症/高甘油三酯/脂蛋白类,HDL胆固醇Key words
Colorectal neoplasm/ Adenoma/ Hyperlipidemia/ Hypertriglyceridemia/ Lipoproteins/HDL cholesterol分类
医药卫生引用本文复制引用
李传凤,李军,白鹏,吕愈敏..结直肠腺瘤与患者血脂代谢水平[J].北京大学学报（医学版）,2011,43(3):432-435,4.
