中国组织工程研究与临床康复2011，Vol.15Issue(20)：3771-3774,4.DOI:10.3969/j.issn.1673-8225.2011.20.039
创面愈合与瘦素促进的跨膜信号途径
Transmembrane signal transduction pathway of leptin effects on wound healing
摘要
Abstract
BACKGROUND: When combined with its receptor, leptin can promote angiogenesis; modulate inflammation and immune function by means of endocrine, paracrine and other ways.OBJECTIVE: To discuss and summarize the effect of leptin on wound healing and the mechanism of leptin transmembrane signal transduction.METHODS: A computer retrieval of CNKI and PubMed databases was performed by using “leptin, wound healing, transmembrane signal” as key words in Chinese and English.RESULTS AND DISCUSSION: Totally 78 articles were retrieved. According to inclusion and exclusion criteria, 22 articles were included after screening. The results showed that leptin plays an important role in wound healing, and it can promote the proliferation and migration of epidermal keratinocytes. We also found that JAK2, STST3, ERK1, and other signal molecules are involved in the transmembrane signal transduction of leptin.关键词
瘦素/创面愈合/跨膜信号传导/表皮角质形成细胞/组织构建分类
医药卫生引用本文复制引用
巫国辉,李小林,刘怡珍..创面愈合与瘦素促进的跨膜信号途径[J].中国组织工程研究与临床康复,2011,15(20):3771-3774,4.基金项目
课题受江西省科技支撑计划(2008-054,2009ZDS15900)和江西省卫生厅科技计划(20083016)资助. （2008-054,2009ZDS15900）
