中国组织工程研究与临床康复2011，Vol.15Issue(20)：3793-3796,4.DOI:10.3969/j.issn.1673-8225.2011.20.045
急性肌肉软组织损伤后不同冷疗方式处理的组织学变化
Histological changes in muscle tissues with acute injury following cryotherapy
石鹏 1沈若武 1季爱玉2
作者信息
- 1. 青岛大学医学院,山东省青岛市266003
- 2. 青岛大学医学院附属医院创伤外科,山东省青岛市,266003
- 折叠
摘要
Abstract
BACKGROUND: Cryotherapy of acute soft tissue injury has been widely used in clinical practice.OBJECTIVE: To observe the histological changes and treatment effect of different cryotherapies on the rats' acute damage of soft tissue. METHODS: Neonatal Wistar rats were randomized to normal, model, intermittent cryotherapy and continuous cryotherapy groups. Models of acute damage of soft tissue were established in model, intermittent cryotherapy and continuous cryotherapy groups. In intermittent cryotherapy group, the injury was treated by intermittent cryotherapy with ice bag at 4 °C; in the continuous cryotherapy group, the injury was treated by continuous cryotherapy with ice bag at 4 °C; the model group was not treated. Histological changes were observed at 48 hours. Injury degree was evaluated using injury symptom index.RESULTS AND CONCLUSION: Compared with model group, the scores of injury symptom index and histology were lower, interleukin-1β expression was reduced, and transforming growth factor-β1 (TGF-β1) expression was increased in intermittent cryotherapy and continuous cryotherapy groups (P < 0.05). Compared with intermittent cryotherapy group, the scores of injury symptom index and histology were reduced (P < 0.05), interleukin-1β expression was reduced (P < 0.05), and TGF-β1 expression was increased in continuous cryotherapy group (P < 0.05). Results demonstrated that cryotherapy can cure the acute damage of soft tissue by reducing interleukin-1β expression and raising TGF-β1 expression. Continuous cryotherapy is superior over intermittent cryotherapy.关键词
软组织损伤/冷疗/白细胞介素1β/转化生长因子β1/肌肉组织/组织构建分类
医药卫生引用本文复制引用
石鹏,沈若武,季爱玉..急性肌肉软组织损伤后不同冷疗方式处理的组织学变化[J].中国组织工程研究与临床康复,2011,15(20):3793-3796,4.
