中国免疫学杂志2011，Vol.27Issue(7)：630-633,4.DOI:10.3969/j.issn.1000-484X.2011.07.012
HLA-A基因多态性与SARS易感性及症状关系的研究
Study on the roles of HLA-A gene polymorphism in the susceptibility and symptom of SARS-Coronavirus infection
摘要
Abstract
Objective:To study the association between HLA-A gene polym orphsm and the susceptibility and symptom of SARS-Coroavirus infection in Northern Chinese Han ethnics.Methods:HLA-A were typed in 53 SARS cases,44 high risks and 77 controls using PCR-SBT m ethods in two case-control studies.Data were analyzed using SPSS version 11.5 and chisquares and OR were used to show the differences and association .Results:The frequency of HLA-A * 2453 allele in SARS patients was markedly higher than that of the high risk care workers(P=0.039,0R=4.479,95％CI 0.95-21.015).How ever,the frequency of HLA-A * 2444 allele in SARS patients was lower than that of the health control( P=0.029 ) .There was no significant difference of the distribution of HLA-A allele frequency in mild cases and severe cases.Conclusion :Genotype of HLA-A * 2453 may be one risk factor for infection of SARS-Cov ,how ever,HLA-A * 2444 may be protect factor for it infection .The severity of SARS may not relate with the genotype of HLA-A.关键词
SARS/HLA-A基因/基因多态性/易感性Key words
SARS /HLA-A /Gene polylym orphism /Susceptibility分类
医药卫生引用本文复制引用
何丽,魏茂提,王世鑫,胡役兰..HLA-A基因多态性与SARS易感性及症状关系的研究[J].中国免疫学杂志,2011,27(7):630-633,4.基金项目
本文受天津市科技攻关重点项目 (05YFSZSF02900)和武警医学院院级项目(WY-2006-16)资助 （05YFSZSF02900）
