中国组织工程研究与临床康复2011，Vol.15Issue(23)：4257-4261,5.DOI:10.3969/j.issn.1673-8225.2011.23.018
异基因造血干细胞移植后EB病毒再激活的危险因素分析
Risk factors for Epstein-barr virus reactivation after allogeneic hematopoietic stem cells transplantation
摘要
Abstract
BACKGROUND: Epstein-barr virus (EBV) reactivation following allogeneic hematopoietic stem cell transplantation (allo-HSCT) can cause deadly post-transplant lymphoproliferative disorders and other EBV-associated diseases. At present, a complete diagnosis and treatment system about EBV reactivation and EBV-related disease has not been established in China. OBJECTIVE: To investigate prospectively the incidence of EBV reactivation and risk factors following allo-HSCT. METHODS: 129 patients receiving allo-HSCT were included. EBV-DNA in peripheral blood were detected by real-time PCR; Kaplan-Meier model was used for analyzing cumulative incidence of EBV reactivation, and binary logistic regression model was used for analyzing risk factors of EBV reactivation.RESULTS AND CONCLUSION: EBV reactivation and EBV associated disease have high incidence rate after allo-HSCT. Risk factors for EBV reactivation include HLA mismatched, use of antithymocyte globulin, grade III-IV acute graft-versus-host disease and age less than or equal to 20 years old.关键词
EB病毒再激活/异基因造血干细胞移植/危险因素/抗胸腺细胞球蛋白/移植物抗宿主病分类
医药卫生引用本文复制引用
曹星辉,范志平,江千里,赵捷,余国攀,韦祁,孙竞,刘启发..异基因造血干细胞移植后EB病毒再激活的危险因素分析[J].中国组织工程研究与临床康复,2011,15(23):4257-4261,5.基金项目
国家863计划-卫生行业科研专项项目(201002024) （201002024）
国家自然科学基金(30971300). （30971300）
