中国全科医学2011，Vol.14Issue(19)：2164-2166,3.
罗格列酮对2型糖尿病患者颈动脉内膜中层厚度及血清可溶性血管细胞黏附分子-1水平的影响
Effects of Rosiglitazone on the IMT and Serum sVCAM-1 Levels in Type 2 Diabetic Patients
赵永才 1李新胜 1张金成 1钱红霞1
作者信息
- 1. 061001,河北省沧州市中心医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the change of carotid intima - media thickness ( IMT ) and serum soluble vascular cell adhesion molecule -1 ( sVCAM -1 ) levels in Type 2 diabetic patients, and to assess the effect of rosiglitazone on IMT and sVCAM - 1 levels.Methods In this study 108 cases of Type 2 diabetic patients were randomly divided into treatment group and control group, every group consisted of 54 numbers.The control group received routine therapy alone.The treatment group was treated with rosightazone 4 mg/d on the basis routine therapy for six months.Serum level of sVCAM - 1, plasma glucose and IMT were measured before and after rosiglitazone intervention on two groups, to observe the differences after treatment between the groups with rosiglitazone treatment and without rosiglitazone treatment Results The level of plasma glucose in Type 2 diabetic patients was significantly lower than that before treatment ( P ＜ 0.05 ).After treatment with rosiglitazone, IMT and serum sVCAM - 1 levels decreased significantly ( P ＜0.05 ).There was no obvious change in IMT and serum sVCAM - 1 levels in control group before and after the treatment ( P ＞ 0.05 ).Using multile linear stepwise regression analysis, the significant correlation between IMT and sVCAM - 1, BMI, 2 hPG, HOMA -IR were discovered ( P ＜0.01 ).Conclusion there is closely relationship between serume sVCAM - 1 levels and Type 2 diabetic macrovascular disease.Serum sVCAM - 1 can be reduced significantly in the Type 2 diabetic patients after being treated with rosiglitazone, which may be one of the protective mechanisms of vascular vessels.关键词
糖尿病,2型/颈动脉内膜中层厚度/可溶性血管细胞黏附分子-1/罗格列酮Key words
Diabetes mellitus, type 2/ Carotid intima - media thickness/ Soluble vascular cell adhesion molecule - 1/ Rosiglitazone分类
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赵永才,李新胜,张金成,钱红霞..罗格列酮对2型糖尿病患者颈动脉内膜中层厚度及血清可溶性血管细胞黏附分子-1水平的影响[J].中国全科医学,2011,14(19):2164-2166,3.
