中国全科医学2011，Vol.14Issue(19)：2169-2171,3.
不同剂量阿托伐他汀对老年2型糖尿病患者维生素D和骨密度的影响
Effects of Different Doses of Atorvastatin on Vitamin D and Bone Mineral Density in Older Patients with Type 2 Diabetes
郭雅卿 1赵丹宁 1巩建萍 1陈向红 1张海容 1尹娟1
作者信息
- 1. 071000,河北省保定市,河北大学附属医院内分泌科
- 折叠
摘要
Abstract
Objective To investigate the effects of different doses of Atorvastatin on Vitamin D and bone mineral density in older patients with type 2 diabetes.Methods The patients ( n = 87 ) with type 2 diabetes were randomly divided into two groups.The patients were given Atorvastatin ( 10 mg/d ) in group A and Atorvastatin ( 20 mg/d ) in group B group for six months, total cholesterol ( TC ), low density lipoprotein ( LDL ), high density lipoprotein ( HDL ), 25 ( OH ) vitamin D3 ( 25 - OH - VD3 ), bone minal density ( BMD ) and HOMA insulin resistance index ( HOMA -IR ) were measured before and after the course of treatment.Results ( 1 ) There was no significant difference before the treatment in blood lipid, 25- OH - VD3 , HOMA - IR and BMD between the two groups ( P ＞0.05 ).After six months treatment, the levels of TC, LDL and HOMA - IR were reduced ( P ＜ 0.01 ) and the levels of HDL, 25 - OH - VD3 an BMD were increased in both groups ( P ＜ 0.05 ); and compared with group A, the levels of TC, LDL and HOMA - IR were observably reduced and the levels of HDL and BMD were obviously increased in group B ( P ＜ 0.01 ).There was no significant difference in 25 - OH - VD3 between the two groups ( P ＞ 0.05 ).( 2 ) Before or after the treatment, the serum 25 - OH - VD3 was positively correlated with BMD and HOMA - IR ( P ＜ 0.01 ) and negatively correlated with BMI ( P ＜ 0.05 ).Before the treatment 25 - OH - VD3 was negatively correlated with TC and LDL ( P ＜ 0.05 ), but after the treatment no correlation was found.Both before and after the treatment 25 鈥?OH 鈥?VD3 was not correlated with HDL.Before and after the treatment BMD was positively correlated with 25 - OH - VD3 and BMI ( P ＜ 0.01 ), and negatively correlated with HOMA - IR ( P ＜ 0.01 ).However it was not correlated with TC, LDL, and HDL.Conclusion Atorvastatin can reduce cholesterol, relieve patients insulin resistance, improve VD level, and increased BMD in patients with type 2 diabetes.关键词
糖尿病,2型/阿托伐他汀/骨密度/维生素DKey words
Mellitus diabetes, type 2/ Atorvastatin/ Bone mineral density/ Vitamin D分类
医药卫生引用本文复制引用
郭雅卿,赵丹宁,巩建萍,陈向红,张海容,尹娟..不同剂量阿托伐他汀对老年2型糖尿病患者维生素D和骨密度的影响[J].中国全科医学,2011,14(19):2169-2171,3.
