摘要
Abstract
Objective: To investigate Curosurf and Phentolamine treatment of respiratory failue in term newborns. Methods: One
hundred and twenty full term newbornn patients with respiratory failure with the blood gas analysis and X ray data were randomly divided
into control group and experimental group. Both groups were received conventional treatment based on the home oxygen therapy.
Experimental group were given phentolamine 3 μg/(min · kg) by infusion pump in 2 hous, q8h, while intratracheal instillation of
Poractant Alfa injection 100 - 200 mg once. Depending on the severity, treatment intervals were gradually extended, until the
withdrawal. Results:The differences of blood gas analysis results between before and after 24 horn's treatment in the experimental group
were as follows: PO2 was (59.1 + 18.7) mm Hg, PCO2 was - (43.9 + 8.5) mm Hg, PO2/FiO2 was (239.7 + 57.7) mm Hg; in the
control group, PO2 was (30.3 + 9.7) mm Hg, PCO2 was - (33.8 + 19.7) mm Hg, and PO2/FiO2 was ( 106.3 +46.9) mm Hg. After
24 hours' treatment the blood gas analysis results were significantly improved, the difference of treatment effect between two groups was
statistically significant(P <0.01 ). Conclusions:The treatment effect of Poractant Alfa injection combinded with Phentolamine for full
term newborns with respiratory failure is good and should be early used.关键词
新生儿/呼吸衰竭/酚妥拉明/猪肺表面活性物质Key words
Neonatal/ Respiratory failure/ Phentolamine/ Puractant Alfa injection分类
医药卫生
