摘要
Abstract
Objective To investigate the prognostic factors of lower respiratory tract infection ( LRTI ) among hospitalized patients.Methods A total of 178 hospitalized patients with LRTI were retrospectively reviewed and divided in two groups according to the outcomes of the disease, namely the improved group ( 152 cases ) and the death group ( 26 cases ).Demographic data.co - morbidities, and baseline clinical and laboratory data on admission were compared hetween the two groups using variance analysis ( quantitative variable ) or chi - square test ( qualitative variable ).Furthermore , multivariable logistic regression was used to identify independent risk factors.Results Univariate analysis revealed that indicators significantly different between the improved group and the death group included : history of LRTI episode within one year, history of invasive ventilator use within one year, family history of asthma, increase of peripheral white blood cell, decrease of hemoglobin , increase of aterial partial pressure of carbon dioxide ( PaCO2 ), decrease of arterial pH, decreases of serum concentrations of Na+.Cl- , aspartate aminotransferase ( AST ), total protein, albumin, blood urea nitrogen ( Bun ), creatinine ( Cr), positive sputum culture and positive occult blood in stools ( P ＜ 0.05 ).Multivariable logistic regression revealed statistical significance for factors including history of LRTI episode within one year, history of invasive ventilator use within one year, family history of asthma, decrease of arterial pH, and positive occult blood in stools ( P ＜ 0.05 ); also in the multivariable analysis, hypoalbuminemia showed a statistical cut - off value ( P = 0.057 ).Conclusion History of LRTI episode within one year, history of invasive ventilator use within one year, family history of asthma, decrease of arterial pH, and positive occult blood in stools are among the independent risk factors of LRTI death.Hypoalbuminemia may influence the prognosis of the patients.Active treatment should be delivered to improve the prognosis of LRTI patients with high risk factors.关键词
下呼吸道感染/预后/危险因素Key words
Lower respiratory tract infection/ Prognosis/ Risk factors分类
医药卫生
