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Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation

Bin Wang Qiang Li Xijing He Weixiong Wang

中国神经再生研究(英文版)2011,Vol.6Issue(16):1217-1221,5.
中国神经再生研究(英文版)2011,Vol.6Issue(16):1217-1221,5.DOI:10.3969/j.issn.1673-5374.2011.16.003

Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation

Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation

Bin Wang 1Qiang Li 1Xijing He 1Weixiong Wang1

作者信息

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摘要

Abstract

Transplantation of olfactory bulb-derived olfactory ensheathing cells (OECs) promotes motor functional recovery in rats with acute spinal cord injury, possibly by Nogo-A expression changes at the injury site. The present study transplanted OECs derived from the olfactory mucosa (OM) of rats. OM-derived OEC (OM-OEC) transplantation significantly reduced the increase of Nogo-A protein and mRNA expression caused by spinal cord injury, supporting the hypothesis that OM-OECs improve spinal cord regeneration by reducing Nogo-A expression.

关键词

Spinal cord injury/olfactory ensheathing cells/olfactory mucosa/cell transplantation/neural regeneration

Key words

Spinal cord injury/olfactory ensheathing cells/olfactory mucosa/cell transplantation/neural regeneration

引用本文复制引用

Bin Wang,Qiang Li,Xijing He,Weixiong Wang..Nogo-A expression in injured spinal cord following human olfactory mucosa-derived olfactory ensheathing cells transplantation[J].中国神经再生研究(英文版),2011,6(16):1217-1221,5.

基金项目

the Doctoral Priming Foundation of Guangzhou Medical University ()

中国神经再生研究(英文版)

OACSCDSCI

1673-5374

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