中国神经再生研究（英文版）2011，Vol.6Issue(16)：1222-1226,5.DOI:10.3969/j.issn.1673-5374.2011.16.004
Oligodendrocyte-like cell transplantation for acute spinal cord injury
Oligodendrocyte-like cell transplantation for acute spinal cord injury
Yongtao Xu 1Anmin Chen 1Feng Li 1Hougeng Lu1
作者信息
摘要
Abstract
In this study, we used insulin-like growth factor-1 to induce bone marrow mesenchymal stem cells (MSCs) to differentiate into oligodendrocyte-like cells. Cell surface marker identification showed that they expressed myelin basic protein and galactosylceramide, two specific markers of oligodendrocytes. These cells were transplanted into rats with acute spinal cord injury at T10. At 8 weeks post-implantation, oligodendrocyte-like cells were observed to have survived at the injury site. The critical angle of the inclined plane, and Basso, Beattie and Bresnahan scores were all increased. Furthermore, latencies of motion-evoked and somatosensory-evoked potentials were decreased. These results demonstrate that transplantation of oligodendrocytic-induced MSCs promote functional recovery of injured spinal cord.关键词
oligodendrocyte/mesenchymal stem cell/spinal cord injury/transplantation/differentiationKey words
oligodendrocyte/mesenchymal stem cell/spinal cord injury/transplantation/differentiation引用本文复制引用
Yongtao Xu,Anmin Chen,Feng Li,Hougeng Lu..Oligodendrocyte-like cell transplantation for acute spinal cord injury[J].中国神经再生研究（英文版）,2011,6(16):1222-1226,5.
