影像科学与光化学2011，Vol.29Issue(3)：212-221,10.
聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究
The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles
摘要
Abstract
In this paper, we grafted various amounts of polyethylene glycol (PEG) onto the surface of gold nanoshells on silica nanorattles (GSNs) and investigated the effects of grafting level about drug loading capacity and stability of GSNs. The results showed that the average thickness of GSNs increased about 4 nm after PEGylation. With the increase of PEGylation,the sedimentation rate of GSNs decreased gradually and the stability increased, and GSNs keeps good stability after standing 35 days. Inductively coupled plasma atomic emission spectrometry (ICP-OES) tests show that it will reach saturation point of PEGylation when the molar ratio of PEG and Au reaches nearly 0. 24. In addition, it has no influence on drug loading capacity about different PEGylation processes. The results of this study will provide an important theoretical basis for the optimization the PEGlyation on the surface of inorganic nanomaterials and for the development of inorganic nano-carrier materials in vivo applications.关键词
聚乙二醇/纳米金壳夹心二氧化硅/稳定性/载药量Key words
polyethylene glycol/ gold nanoshells on silica nanorattles/ stability/ drug loading capacity分类
化学化工引用本文复制引用
陈帅娜,刘惠玉,陈东,吴小莉,唐芳琼,杨文智..聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究[J].影像科学与光化学,2011,29(3):212-221,10.基金项目
自然科学基金青年基金(30800258,30900348,81000667) （30800258,30900348,81000667）
自然科学基金面上基金(20873171). （20873171）
