首页|期刊导航|中国神经再生研究（英文版）|Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation
中国神经再生研究（英文版）2011，Vol.6Issue(16)：1227-1231,5.DOI:10.3969/j.issn.1673-5374.2011.16.005
Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation
Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation
摘要
Abstract
Bone marrow mesenchymal stem cells (MSCs) from rats were transfected with Rn-siRNA-caveolin-1 and differentiated into neuron-like cells using fasudil hydrochloride. Membrane ultrastructural changes in MSCs were observed under atomic force microscopy. Caveolin-1-transfected rat MSCs exhibited weak nuclear refraction, dense caveolae and long finger-like cellular processes prior to fasudil hydrochloride treatment. MSCs differentiating into neuron-like cells exhibited weak nuclear refraction and large cellular processes without caveolae. We hypothesize that caveolin-1 plays an important role in the regulation of bone marrow MSC differentiating into neuron-like cells.关键词
atomic force microscopy/bone marrow mesenchymal stem cells/caveolin-1/neurons/differentiation/neural regenerationKey words
atomic force microscopy/bone marrow mesenchymal stem cells/caveolin-1/neurons/differentiation/neural regeneration引用本文复制引用
Jingjing Lu,Lijun Jing,Yonglin Jia,Jinyi Li,Liudong Wang,Tao Peng,Yanjie Jia..Effects of caveolin-1 on bone marrow mesenchymal stem cells differentiating into neuron-like cells An atomic force microscopy observation[J].中国神经再生研究（英文版）,2011,6(16):1227-1231,5.基金项目
the National Natural Science Foundation of China,No.30770758 （）
the Natural Science Research Program of Henan Provincial Department of Education,No.2008A320032 （）
