中国全科医学2011，Vol.14Issue(23)：2595-2597,3.
重组组织型纤溶酶原激活剂超早期静脉溶栓治疗急性脑梗死的疗效研究
Efficacy of Intravenous Thrombolysis by rt-PA in Treating Acute Cerebral Infarctions within Six Hours from Symptom Onset
肖凯文 1唐玉兰 2张先龙2
作者信息
- 1. 412000,湖南省株洲市一医院
- 2. 广西医科大学第一附属医院神经内科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy and safety of Actilyse ( recombinant tissue plasminogen activator, rt PA ) in early treatme.nt of patients with acute cerebral infarctions.Methods Sixty - four qualified patients were randomly divided into the observation group and the control group.The observation group were treated with rt - PA ( 0.9 mg/kg ) ( no more than 90 mg ).Firstly, intravenous injection was performed hy which 10％ of the drug was administered within 1 minute ; then the remaining 90％ was injected continuously in 60 minutes.The control group was treated with aspirin ( 300 mg/d ).The Chinese Stroke Scale ( CSS ) and the Barthel Index ( BI ) were used to evaluate the neurological functions before and 90 days after treatment.Results CSS scores and BI of the observation group and the control group showed no significant difference before treatment ( P ＞0.05 ) and were significantly different after treatment ( P ＜0.01 ).In the observation group, recovery was seen in 13 cases, the treatment was found to be remarkably effective in 11 cases.effective in 6 cases, and no changes were observed in the left 2 cases; in the control group, 8 cases recovered, the treatment was found to be remarkably effective in 9 cases, effective in 11 cases, and no changes were ohserved in the other 4 cases; efficacy between the two groups was significantly different ( u =2.34, P ＜0.05 ).Conclusion Intravenous rt - PA thrombolysis in patients with acute cerebral infarctions within 6 hours from onset is both effective and safe.and the efficacy is superior to that of the control group.关键词
重组组织型纤溶酶原激活剂/静脉溶栓/急性脑梗死Key words
Recombinant tissue plasminogen activator/ Intravenous thrombolysis/ Acute cerebral infarction分类
医药卫生引用本文复制引用
肖凯文,唐玉兰,张先龙..重组组织型纤溶酶原激活剂超早期静脉溶栓治疗急性脑梗死的疗效研究[J].中国全科医学,2011,14(23):2595-2597,3.
