中国肺癌杂志2011，Vol.14Issue(6)：538-542,5.DOI:10.3779/j.issn.1009-3419.2011.06.11
非小细胞肺癌治疗的新靶点:EML4-ALK融合基因
A New Target in Non-small Cell Lung Cancer: EML4-ALK Fusion Gene
摘要
Abstract
It was only 3 years ago that the fusion gene between echinoderm microtubule-associated protein-like4 (EML4) and anaplastic lymphoma kinase (ALK) has been identified in a subset of non-small cell lung cancer (NSCLC).EML4-ALK is most often detected in never smokers with lung adenocarcinoma and has unique pathologic features.EML4ALK fusion gene is oncogenic, which could be suppressed by ALK-inhibitor through blocking the downstream signaling passway of EML4-ALK.This review will focus on the molecular structure, function, biology, detection method and the diagnostic and therapeutic meaning of EML4-ALK of lung cancer.关键词
EML4-ALK融合基因/间变性淋巴瘤激酶/肺肿瘤Key words
EML4-ALK/ Anaplastic lymphoma kinase/ Lung neoplasms分类
医药卫生引用本文复制引用
王慧娟,袁静..非小细胞肺癌治疗的新靶点:EML4-ALK融合基因[J].中国肺癌杂志,2011,14(6):538-542,5.
