中国肺癌杂志2011，Vol.14Issue(6)：512-517,6.DOI:10.3779/j.issn.1009-3419.2011.06.17
c-Cbl、Cbl-b和EGFR在非小细胞肺癌中的表达及其预后价值
Expressions of c-Cbl, Cbl-b and EGFR and Its Role of Prognosis in NSCLC
摘要
Abstract
Background and objective Epidermal growth factor receptor (EGFR) is closely correlated with the progression of lung cancer.Its activity is modulated by Casitas B-lineage lymphoma (Cb1) family.The aim of this study is to investigate the expression and clinical relevance of c-Cb1, Cb1-b and EGFR in non-small cell lung cancer (NSCLC).Methods Expressions of c-Cbl, Cb1-b and EGFR protein were detected with tissue microarrays and immunohistochemistry technique in 94 cases of NSCLC.The correlations between the expression of the three proteins and clinicopathological parameters were analyzed.Results The positive expression rates of EGFR, c-Cbl and Cbl-b were 60.6％ (57/94), 30.9％ (29/94) and 84.0％ (79/94), respectively.The expression of EGFR, c-Cb1 and Cb1-b was not associated with age, pathological type, TNM stage,lymph node metastasis, and smoking history c-Cbl and Cbl-b status was not significantly correlated with overall survival.Subgroup analyses showed that c-Cbl-positive patients had longer survival than c- Cbl-negative patients in EGFR-positive group (P=0.014).Conclusion Detection of c-Cbl protein levels might contribute to the prognosis evaluation of EGFR-positive NSCLC.关键词
肺肿瘤/表皮生长因子受体/c-Cbl/Cbl-b/预后Key words
Lung neoplasms/ Epidermal growth factor receptor (EGFR)/ c-Cbl/ Cbl-b/ Prognosis分类
医药卫生引用本文复制引用
焦昕,金波,曲秀娟,闫顺朝,侯科佐,刘云鹏,胡雪君..c-Cbl、Cbl-b和EGFR在非小细胞肺癌中的表达及其预后价值[J].中国肺癌杂志,2011,14(6):512-517,6.基金项目
本研究受辽宁省科技攻关计划项目(No.2005225013-7)、辽宁省教育厅基金(No.20060992和No.20060945)资助 （No.2005225013-7）
