摘要
Abstract
Objective To analyze the clinical data of pseudohypoparathyroidism and to explore ways toward early diagnosis and treatment. Methods Clinical data of 5 pseudohypoparathyroidism cases hospitalized in the First Affiliated Hospital of Xinjiang Medical University and the Second Hospital of Xiangya between January 2001 and June 2010 were collected to conduct a retrospective analysis upon their clinical manifestations, lab results, imaging results, diagnostic methods and treatment methods.Results Different length of disease duration were reported among the 5 patients upon first visit ( 2 months to 9 years ). The disease turned out to be early - onset in all cases. History of hand and foot spasms, recurrent seizures, and weakness were also complained in these cases. Lab results indicated the existence of hypocalcemia, hyperphosphatemia and elevated serum parathyroid hormone. X - ray films of hand , feet, skull and the whole skelotan system showed multiple calcification sites in soft tissues.On first visit, 2 of patients showed hand and foot spasms and seizure, another 2 showed congenital developmental abnormality characterized as Albright's hereditary osteodystrophy with short stature , round face , short neck, short palm and digital bones of hand and foot bones ( especially the first, fourth and fifth fingers ). Currently, no effective treatment is available for this disease. Intravenous calcium and diazepam can be administered to control the tetany during acute onset, while life time treatment for the non - acute phase includes calcium and vitamin D supplement and decreased phosphate rich food intake. Conclusion PHP has a variety of clinical manifestations, including hand and foot spasms and seizures poorly responsive to seizure control medications. Tests for blood calcium, phosphorus and PTH levels as well as brain CT examinations should be carried out early in AHO cases in favor of early diagnosis and early treatment.关键词
假性甲状旁腺功能减退症/诊断/治疗Key words
Pseudohypoparathyroidism/ Diagnosis/ Treatment分类
医药卫生
