厦门大学学报（自然科学版）2011，Vol.50Issue(3)：607-611,5.
黑腹果蝇中辅酶Q的鉴定及其对寿命的影响
Characterization of Coenzyme Q and Preliminary Investigation on Its Effect on Life-span in Drosophila melanogaster
摘要
Abstract
Coenzyme Q is an essential component of the mitochondrial respiratory chain as a lipid-soluble electron transporter located in the inner membrane of mitochondria. The number of isoprenoid subunits in the coenzyme Q side chain varies in different species. The content of coenzyme Q in Drosophila has not been reported yet. In the present report , we analyzed the content of coenzyme Q in adult Drosophila by HPLC. We provided evidence that Drosophila contains both CoQ9 and CoQ10. The amount of CoQ9 is about 2. 5 folds than that of CoQ10. We further showed the content of CoQ9 and CoQ10 in females are respectively about 30 ％ , 33 ％higher than that in males. In addition,both concentrations of CoQ9 and CoQ10 are significanrly reduced in the mutant of CoQ synthase gene coqZ which appeared with shorrened life-span. These results provided a good basis to further invesrigate in vivo biological functions of CoQ in Drosophila.关键词
辅酶Q/果蝇/高效液相色谱/寿命Key words
coenzyme Q/ Drosophila / HPLC / life- span分类
生物科学引用本文复制引用
程威,李冬梅,宋传超,韩伟,杨丽容,陈建明..黑腹果蝇中辅酶Q的鉴定及其对寿命的影响[J].厦门大学学报（自然科学版）,2011,50(3):607-611,5.基金项目
国际科技合作项目(2009DFA32760) （2009DFA32760）
