首页|期刊导航|中国神经再生研究（英文版）|Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury
中国神经再生研究（英文版）2011，Vol.6Issue(17)：1306-1312,7.DOI:10.3969/j.issn.1673-5374.2011.17.005
Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury
Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury
摘要
Abstract
High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects. In this study, we investigated intrathecal delivery of methylprednisolone for the treatment of spinal cord injury. In particular, we examined the effects of varying doses of methylprednisolone intrathecal injections on neuronal apoptosis induced by secondary damage. The results demonstrate that intrathecal injections inhibit the expression of interleukin-1β, significantly lower expression of caspase-3, and reduce the number of apoptotic neurons. High dose methylprednisolone (0.75 mg/μL) was much more effective at reducing neuronal apoptosis than low dose methylprednisolone (0.01 mg/μL).关键词
spinal cord injury/apoptosis/interleukin-1 receptor antagonist/caspase-3/methylprednisolone/neural regenerationKey words
spinal cord injury/apoptosis/interleukin-1 receptor antagonist/caspase-3/methylprednisolone/neural regeneration引用本文复制引用
Xinghua Song,Jianjun Zhang,Liwen Ding,Li Cao,Xiaoxiong Xu,Hao Wen..Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury[J].中国神经再生研究（英文版）,2011,6(17):1306-1312,7.基金项目
the Research Fund of First Affiliated Hospital,Xinjiang Medical University,China,No.2008-YFY-05 （）
and the Postgraduate Fund of the First Affiliated Hospital,Xinjiang Medical University,No.2010PGF01 （）
