应用化学2011，Vol.28Issue(4)：382-386,5.DOI:10.3724/SP.J.1095.2011.00372
4-取代-2-氨基嘧啶衍生物的合成
Synthesis of 4-Substituted-2-Amino-pyrimidines
摘要
Abstract
N,N-Dimethylformamide-dimethyl acetal(DMF-DMA) was refluxed with the corresponding aromaticor heterocyclic compounds to prepare the intermediates 3-( dimethylamino)-l-( substituted) prop-2-en-l-onewith a yield of 71. 2％～85.2％. By refluxing the obtained intermediates with guanidine hydrochloride inethanol and in the presence of sodium ethoxide, fourteen 4-substituted-2-amino-pyrimidines were obtained ingood yield of 66. 6％ ～ 86. 1 ％ . All the products were confirmed by NMR, mass spectrometry, and elementalanalysis.关键词
取代氨基嘧啶/合成/表征Key words
substituted-amino-pyrimidines, synthesis, characterization分类
化学化工引用本文复制引用
陈启凡,张慧东,宫胜臣..4-取代-2-氨基嘧啶衍生物的合成[J].应用化学,2011,28(4):382-386,5.基金项目
"十五"国家科技攻关计划(2004BA304B) （2004BA304B）
