应用化学2011，Vol.28Issue(4)：387-393,7.DOI:10.3724/SP.J.1095.2011.00347
离子型有机锡化合物的合成及其生物活性
Synthesis and Biological Activity Study of Ionic Organotin Compounds
摘要
Abstract
A series of ionic organotin ( ]V ) complexes with general formula [ HNR3 ] [ ( PhCH2 )3Sn (μ2 -SCH2COO) Cl ], [ HNR3 ] [ ( Ph3Sn)3 ( O2CCH2CO2)2] · CH3CH2OH and [ HNR3 ] [ MeCy2ClSnO2CCH2-CO2SnClCy2Me] were synthesized by the reaction of organic acid with organotin halide in the presence of an organic base. The results of the anti-tumor, bactericidal and acaricidal activity show that some complexes have good biological activity. The inhibition rate of [ HNR3 ] [ ( Ph3Sn)3 ( O2CCH2CO2 )2 ] · CH3CH2OH and [HNR3] [MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for A-549, HCT-8 and Bel-7402 was about 90％ , the mortality rate of [ HNR3 ] [ MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for Gibberella zeae, Alternaria solani, Phomopsis asparagi, Physalospora piricola, Cercospora arachidicol was 100％ , the mortality rate of [ HNR3 ] [ MeCy2ClSnO2CCH2CO2SnClCy2Me] complexes for acaricidal activity was more than 90％.关键词
离子型有机锡/生物活性/抗肿瘤活性/杀菌活性/杀螨活性Key words
ionic organotin,biological activity,anti-tumor activity,bactericidal activity,sterilization activity分类
化学化工引用本文复制引用
钟桂云,孙丽娟..离子型有机锡化合物的合成及其生物活性[J].应用化学,2011,28(4):387-393,7.基金项目
国家自然科学基金(20372035)资助项目 （20372035）
