首页|期刊导航|中国神经再生研究（英文版）|Optimal time point for the transplantation of neural stem cells induced to differentiate with retinoic acid
中国神经再生研究（英文版）2011，Vol.6Issue(16)：1243-1247,5.DOI:10.3969/j.issn.1673-5374.2011.16.008
Optimal time point for the transplantation of neural stem cells induced to differentiate with retinoic acid
Optimal time point for the transplantation of neural stem cells induced to differentiate with retinoic acid
摘要
Abstract
Previous studies have demonstrated that differentiated neural stem cells (NSCs) are more suitable for transplantation than non-differentiated NSCs. In this study, NSCs were expanded in vitro for two passages, induced with retinoic acid to differentiate, and harvested between 1-6 days later. They were subsequently cultured in artificial cerebrospinal fluid for an additional 3 days, during which their growth and morphology was monitored. NSCs induced for 4 days exhibited a peak rate of cells differentiating into neurons and robust growth. Our results indicate that the optimal time point for transplanting NSCs is following a 4-day period of induced differentiation.关键词
neural stem cells/retinoic acid/artificial cerebrospinal fluid/induced differentiation/cell transplantation/optimal time point/neural regenerationKey words
neural stem cells/retinoic acid/artificial cerebrospinal fluid/induced differentiation/cell transplantation/optimal time point/neural regeneration引用本文复制引用
Shuxin Wang,Dengji Pan,Na Liu,Yongming Liu,Juan Chen,Houjie Ni,Zhouping Tang..Optimal time point for the transplantation of neural stem cells induced to differentiate with retinoic acid[J].中国神经再生研究（英文版）,2011,6(16):1243-1247,5.基金项目
the National Natural Science Foundation of China,No.30570628,30770751 （）
