北京中医药大学学报2011，Vol.34Issue(5)：326-332,7.
基于类药有效组分特征图谱的中药复方质量表征模式研究
Quality representation model of TCM formulas based on characteristic spectrum of drug-like effective components
摘要
Abstract
Objective To establish the quality representation model of TCM formulas based on the characteristic spectrum of drug-like effective components taken Kai Xin San as a study carrier. Methods The model of dysmnesia was established by using scopolamine in SD rats, and then the rats were given intragastrically the extract of Kai Xin San for collecting medicinal serum. The intestinal absorption fluid of Kai Xin San was prepared by applying modified everted intestinal sac. The HPLC characteristic spectrum was determined and compared with the HPLC characteristic spectrum of extract of Kai Xin San. Results There were 14 chemical compositions screened from the drug-like effective components in Kai Xin San and 5 characteristic compositions identified among them, and then the screened drug-like effective components were given pharmacodynamics validation by using serum pharmacological method. The characteristic spectrum of drug-like effective components was set up, and based on which the quality representation model of Kai Xin San was formed. Conclusion The quality representation model of TCM formulas based on the characteristic spectrum of drug-like effective components is scientific, reasonable and feasible, which can reflect the quality characteristics of TCM formulas, and can be taken as a new thought train and process for quality control of TCM formulas.关键词
类药有效组分/类药筛选/特征图谱/质量表征模式/开心散Key words
drug-like effective components/ similar medication screening/ characteristic spectrum/ quality representation model/ Kai Xin San分类
医药卫生引用本文复制引用
戴莹,姜艳艳,刘洋,巴寅颖,吕航,闫陶,陈小虎,石任兵..基于类药有效组分特征图谱的中药复方质量表征模式研究[J].北京中医药大学学报,2011,34(5):326-332,7.基金项目
国家重大新药创制项目(No.2009ZX09502-006),国家"211"工程建设项目 （No.2009ZX09502-006）
