中国全科医学2011，Vol.14Issue(24)：2791-2792,2.
急性早幼粒细胞白血病黏附分子的表达及其临床意义
Expression and Clinical Significance of Cell Adhesion Molecules in Acute Promyelocytic Leukemia
许力 1林金盈 1阳文捷 1蓝娇 1李永敢 1莫文健2
作者信息
- 1. 530021,广西南宁市,广西壮族自治区人民医院血液科
- 2. 广州市第一人民医院血液科
- 折叠
摘要
Abstract
Objective To investigate the expression and clinical significance of cell adhesion molecules in acute promyelocytic leukemia ( APL ) cells before and after the treatment of alltrans retinoic acid ( ATRA ) and Daunorubicin. Methods Thirty - two APL patients were divided into two groups according to the levels of white blood cells ( WBC ) on admission : the high risk group ( WBC ＞ 10 × 109/L ) and the low risk group ( WBC ＜ 10 × 109/L ). Expression levels of adhesion molecules including CD49d, CD11b, CD11a , CD54 , CD15 , and CD62L before and after ATRA and Daunorubicin treatment were measured by flow cytometry. Results Before treatment, CD49d, CD11b, , CD11a and CD54 were positively expressed, with expression levels in the high risk group higher than in the low risk group ( P ＜ 0.05 ), while CD15 and CD62L were negatively expressed in all APL cells. Three days after ATRA treatment, expression levels of adhesion molecules were increased significantly with the high risk group higher than the low risk group ( P ＜ 0.05 ). Cells were further treated with Daunorubicin for a week after the 3 - day ATRA treatment with the same indices measured again. Expression levels of adhesion molecles were decreased ( P ＜ 0.05 ), but still higher than before ATRA treatment. Conclusion All APL cells express the CD49d, CD11b , CD11a and CD54 molecules. The expression levels of CD49d and CD54 increased significantly after ARTA administration and an additional chemotherapy can ruduce the levels of CD54 and CD49d expression.关键词
白血病,早幼粒细胞,急性/黏附分子/维甲酸/化疗Key words
Leukemia, promyelocytic, acute/ Adhesion molecule/ Alltrans retinoic acid/ Chemotherapy分类
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许力,林金盈,阳文捷,蓝娇,李永敢,莫文健..急性早幼粒细胞白血病黏附分子的表达及其临床意义[J].中国全科医学,2011,14(24):2791-2792,2.
