中国全科医学2011，Vol.14Issue(24)：2754-2757,4.
依那西普联合来氟米特治疗强直性脊柱炎的临床分析
Etanercept Combined with Leflunomide in Treatment of Ankylosing Spondylitis
摘要
Abstract
Objective To investigated the clinical efficacy and safety of etanercept combined with leflunomide in treating ankylosing spondylitis ( AS ) . Methods Forty - five patients with AS were randomly divided into 3 groups: group A received etanercept treatment, group B received etanercept combined with leflunomide and group C received diclofenac combined with leflunomide. Eight weeks later, etanercept and diclofenac were withdrawn in group B and group C respectively. At week 0,4,8 and 12, efficacy and safety were assessed according to the clinical manifestations and lahoratory measurements. Results Clinical data at haseline showed no statistic differences among the 3 groups ( P ＞ 0.05 ) . Assessment of Ankylosing Spondylitis ( ASAS ) showed that ASAS 20 and ASAS 50 improvement rates in group A and B were higher than those in group C ( P ＜ 0.05 ),while no difference was seen between group A and B ( P ＞ 0.05 ) . At the end of study, no difference among the ASAS 20 improvement rates among the three groups was seen (P＞0.05) . ASAS 50 improvement rates in group A and B were higher than that in group C, while no difference was observed between group A and B ( P＞0.05 ) . Adverse reactions in group A and B showed no significant differences in incidence rates ( P＞0.05 ) and included erythra, liver disfunction and upper respiratory infections. Adverse reactions in group C included gastrointestinal illness and liver disfunction with higher incidence rates than those of group A and B ( P ＜ 0.05 ) . Conclusion Etanercept shows a quick effect and few adverse reaction in the treatment of AS. Short - term therapy of etanercept combined with leflunomide shows comparable curative effects and similar adverse reaction rates compared with long - term therapy of etanercept alone. Therefore it might be reasonable to shorten the therapeutic duration of etanercept so as to relieve the economic burden of the patients.关键词
受体,肿瘤坏死因子/依那西普/来氟米特/脊柱炎,强直性/治疗结果Key words
Receptors, tumor necrotic factor/ Etanercept/ Leflunomide/ Spondylitis, ankylosing/ Treatment outcome分类
医药卫生引用本文复制引用
吴春玲,杨娉婷,刘海娜,赵丽娟,肖卫国..依那西普联合来氟米特治疗强直性脊柱炎的临床分析[J].中国全科医学,2011,14(24):2754-2757,4.基金项目
国家自然科学基金资助项目(30801204) （30801204）
