中国组织工程研究与临床康复2011，Vol.15Issue(23)：4295-4298,4.DOI:10.3969/j.issn.1673-8225.2011.23.026
粒细胞集落刺激因子动员2型糖尿病患者外周血CD34+细胞的变化
Granulocyte colony-stimulating factor mobilizes peripheral blood CD34+ cells in patients with type 2 diabetes mellitus
摘要
Abstract
AbstractBACKGROUND: The number of mobilized peripheral blood CD34+ cells significantly decreases in type 2 diabetes mellitus patients compared with normal subjects.OBJECTIVE: To investigate the changes of mobilized peripheral blood CD34+ cells in type 2 diabetes mellitus patients. METHODS: A total of 234 patients with type 2 diabetes mellitus were divided into five categories according to disease duration, newly diagnosed type 2 diabetes (≤1 year) and diabetes duration (1-5, 5-10, 10-15, ≥15 years). CD34+ cells were mobilized with granulocyte colony-stimulating factor. Five days later, the number of peripheral blood CD34+ cells was detected with flow cytometry. Its relationship with disease duration, blood lipids and uric acid was analyzed by person-related analysis and multiple regression analysis.RESULTS AND CONCLUSION: The number of mobilized peripheral blood CD34+ cells was associated with the triacylglycerol (r=-0.202, P=0.002), the apoprotein-B (r=-0.276, P=0.000), and the uric acid (r=-0.297, P=0.000). Statistical analysis found that, the number of mobilized peripheral blood CD34+ cells decreased with development of diabetes mellitus.关键词
粒细胞集落刺激因子/2型糖尿病/CD34+细胞/动员/病程/相关性分类
基础医学引用本文复制引用
窦立冬,崔晓兰,陈建河,王立梅,王意忠..粒细胞集落刺激因子动员2型糖尿病患者外周血CD34+细胞的变化[J].中国组织工程研究与临床康复,2011,15(23):4295-4298,4.基金项目
航天科工集团科研基金项目(2009-JKBZ-003). （2009-JKBZ-003）
