医药导报2011，Vol.30Issue(8)：997-999,3.DOI:10.3870/yydb.2011.08.008
复方利多卡因乳膏体外透皮吸收实验
Percutaneous Absorption of the Compound Lidocaine Cream in Vitro
舒成仁 1葛苗苗 2黄露 2吴海燕 3黎维勇2
作者信息
- 1. 湖北省黄石市中心医院药剂科,435000
- 2. 华中科技大学同济医学院附属协和医院药剂科,武汉430022
- 3. 湖北省医药工业研究院,武汉430061
- 折叠
摘要
Abstract
Objective To compare the percutaneous absorbency of the compound lidocaine cream between the lab made and commercially available one during different periods of storage. Methods The permeation of the cream was studied on rat skin with Franz diffusing cell. Lidocaine and prilocaine was quantified by HPLC. The percutaneous absorbency in vitro was evaluated by transdermal absorption accumulation of lidocaine and prilocaine. Results There were no significant difference in the transdermal absorption accumulation between the test cream and the reference one ( P＞0.05 ). And no significant difference was found in the transdermal absorption and drug release whenever within the expiry date ( P ＞ 0.05 ). Conclusion The percutaneous absorbency of the test cream is consistent with the reference cream, and which is stable during storing within the period of validity.关键词
利多卡因/丙胺卡因/乳膏/色谱法,高效液相/透皮吸收Key words
Lidocaine/ Prilocaine/ Cream/ HPLC/ Percutaneous absorpotion分类
医药卫生引用本文复制引用
舒成仁,葛苗苗,黄露,吴海燕,黎维勇..复方利多卡因乳膏体外透皮吸收实验[J].医药导报,2011,30(8):997-999,3.
