医药导报2011，Vol.30Issue(8)：1027-1029,3.DOI:10.3870/yydb.2011.08.020
沙美特罗/氟替卡松对支气管哮喘患者血清IL-21与总IgE 水平的影响
Effect of Salmeterol/fluticasone on Serum Levels of Interleukin-21 and Total IgE in Asthmatic Patients
摘要
Abstract
Objective To investigate the combined effect of sahneterol/fluticasone( SF ) therapy on serum levels of interleukin-21 ( IL-21 ) and total IgE in asthmatics, and to explore the relationship between them in patients with allergic asthma.Methods A total of 95 blood samples were collected and divided into three groups: control group ( n= 20 ) , allergic asthma group ( n =45 ) and treatment group ( n= 30 ).Patients belonging to the treatment group were treated with a combination of 50 μg sahneterol and 250 μg fluticasone twice daily for three months, and it was found that their asthma symptoms were alleviated.The levels of IL-21 and total IgE in blood were detected by enzyme-linked immunosorbent assay ( ELISA ).Results The serum levels of IL-21 in control group, allergic asthma group and treatment group were 17.19, 21.99 and 17.18 pg · mL-1,respectively.The levels of IL-21 significantly differ from each other between the control group and allergic asthma group ( P＜0.05 ).Negative relationship was found between the levels of IL-21 and total serum IgE in allergic asthma group ( r= -0.32, P＜0.05 ).In addition, IL-21 level were significantly reduced by SF in treatment group compared to allergic asthma group (P＜0.05 ), while SF did not significantly change total IgE levels ( P＜0.05 ).Conclusion Our results suggested that combined effect of sahneterol/fluticasone inhalation can reduce levels of IL-21 in asthmatic patients, and it might be one of the important mechanisms for the treatment of asthma.关键词
沙美特罗/氟替卡松/哮喘/白细胞介素21/免疫球蛋白EKey words
Sahneterol/fluticasone/ Asthma/ Interleukin-21/ IgE分类
医药卫生引用本文复制引用
李开艳,熊盛道,朱晶,曹勇,熊维宁..沙美特罗/氟替卡松对支气管哮喘患者血清IL-21与总IgE 水平的影响[J].医药导报,2011,30(8):1027-1029,3.基金项目
国家自然科学基金资助项目(基金编号:30770946,30900647) （基金编号:30770946,30900647）
