摘要
Abstract
Objective To explore the influence of 6％ hydroxyethyl starch 130/0.4 on renal function of elderly patients undergoing esophageal cancer surgery. Methods The 54 elderly patients received esophageal cancer surgery were enrolled and randomly divided into two groups and undertook acute hypervolemic hemodilution( AHH ). 6％ hydroxyethyl starch 130/0.4 sodium chloride injection and sodium lactate ringer's injection were given to the test and control groups, respectively. The heart rate( HR ), saturation of arterial blood oxygen( SaO2 ), mean arterial pressure( MAP ), central venous pressure( CVP ), creatinine ( Cr ),blood urea nitrogen( BUN ),uric acid( UA )and Cysteine protease inhibitors C( Cystatin-C ) were monitored at before AHH ( t1 )、post AHH( t2 )、2 hours after AHH( t3 )、4 hours after AHH(t4 ) and 24 hours after AHH( t5 ). Results There was no significant difference occured for MAP and HR between the two groups. CVP in both groups was increased significantly at t2-t4 compared with that at t1 and t5. CVP in the test group was higher than that in the control group at t2, t3 and t4. No remarkable changes for Cr,BUN and UA were found whatever time points, inter-groups or intra-groups. Serum concentrations of were normal during the study. Cys-C at t5 in both groups were higher than that at t1 -t4, and there was no significant difference between two groups. Conclusion AHH with 6％ hydroxyethyl starch 130/0.4 has no obvious harmful effect on renal function of the elderly patients who undertaken surgical treatment for esophageal cancer.关键词
6%羟乙基淀粉130/0.4/血液稀释/高容量,急性/肾功能/癌/食管Key words
6％ hydroxyethyl starch130/0.4/ Hemodilution, hypervolemic, acute/ Renal function/ Cancer, sophageal分类
医药卫生
