河北医学2011，Vol.17Issue(6)：726-728,3.DOI:10.3969/j.issn.1006-6233.2011.06.006
缺血性脑卒中患者阿司匹林抵抗与血小板膜糖蛋白CD62pCD63及GPⅡb Ⅲa的相关性研究
Research of the Relationship of Aspirin Resistance and Platelet Membrane Glycoprotein CD62p, CD63 and GPⅡ b Ⅲ a in Patients with Ischemic Stroke
摘要
Abstract
Objective: To investigate the relationship between changes of platelet membrane glycoprotein CD62p, CD63 and GP Ⅱ b / Ⅲ a and aspirin resistance the patients with ischemic stroke. Method: We randomly selected 60 cases with ischemic stroke and 30 cases physical health of the same period from Jan.2009 to Dec. 2010 in our hospital. Positive expression rate of CD62p, CD63 and GP Ⅱ b/Ⅲ were detervmined by FCM in the crowd. 60 cases received aspirin ( lOOmg, qd) for 2 weeks, then given flow cytometry test. They were divided into aspirin resistance group (AR group) and aspirin-sensitive group (AS group) , and AR group had 8 cases while AS group had 52 cases. The 30 healthy people were considered as the control group. Determined the positive expression rate of D62p, CD63 and GP Ⅱ b / Ⅲ in the three groups. Results: ① The positive expression rate of CD62p, CD63 and GP Ⅱ b / Ⅲ in 60 patients was significantly lower than those of before the treatment, however, it was higher than the control group, there were statistically significant differences between the data ( P＜0.O1 ). ② AR group of patients with platelet GP Ⅱ b / Ⅲ a expression was higher than which was in the AS group ( P ＜0. Ol ) . Conclusion: GP Ⅱ b / Ⅲ a can be used as the reference of ischemic stroke patients treated with aspirin early.关键词
缺血性脑卒中/阿司匹林抵抗/血小板膜糖蛋白Key words
Ischemic stroke/ Aspirin resistance/ Platelet membrane glycoprotein引用本文复制引用
谷玉平,何小燕..缺血性脑卒中患者阿司匹林抵抗与血小板膜糖蛋白CD62pCD63及GPⅡb Ⅲa的相关性研究[J].河北医学,2011,17(6):726-728,3.基金项目
广东省科研项目:编号 y10043 （）
