中国心理卫生杂志2011，Vol.25Issue(6)：401-408,8.DOI:10.3969/j.issn.1000-6729.2011.06.001
广州市幼儿园儿童孤独症谱系障碍患病率和相关因素
Prevalence of autism spectrum disorders in preschool children of Guangzhou kindergartens
王馨 1胡敏 1李诗韵 1修丽娟 1郭嘉 1梁华妮 1宁静 1程舒媛 1樊越波 2杨文翰 1金宇 1静进 1黄旭 1李秀红 1魏薇 1暴芃 1王惠1
作者信息
- 1. 中山大学公共卫生学院妇幼卫生学系,广州,510080
- 2. 广州市儿童孤独症康复研究中心,广州,510540
- 折叠
摘要
Abstract
Objective: To investigate the epidemic characteristics and related factors of autism spectrum disorders (ASDs) in preschool children of Guangzhou mainstream kindergartens. Methods: In this cross-sectional study, 7500 children aged 2 -6 years were selected from 21 kindergartens of 6 regions in Guangzhou City by multistage sampling method, who were preliminarily screened with the Clancy Autism Behavior Rating Scale( CABRS),children growth and development questionnaire and teacher nomination strategy. The children were observed, evaluated, and diagnosed to get the prevalence and related factors. Results: ( 1 ) The prevalence of ASDs in preschool children in Guangzhou mainstream kindergartens was 75.4/10000 (95％ CI 53.8/10 000 -97.0/10000), and the rates were 29. 5/10000 (95％ CI 16. 1/10000 -43.1/10000) for autism, with the proportion of 16. 7％ for high functioning autism (HFA), 41.0/10000 (95％ CI 25.0/10 000 - 57. 0/10 000) for Asperger syndrome (AS), 4. 9/10000 (95 ％ CI 0/10000 - 10. 6/10000) for pervasive developmental disorder-not otherwise specified (including atypical autism). The sex ratio of male to female was 6. 6: 1. (2) The teacher nomination strategy was used to preliminarily screen ASDs, and the sensitivity was 95.6％, specificity was 91.1％, Youden＇ s index was 0. 867. (3)The proportion of higher maternal (25 - 29 years and 30 - 34 years) and paternal age (30 - 34 years and ≥ 35 years), higher maternal education ( bachelor and above) and maternal emotional instability during the pregnant time in ASDs group were higher than those in the normal group (P ＜ 0. 05), and logistic analysis showed that male children, higher paternal age and maternal emotional instability were the risk factors to ASDs in children. Conclusion:The prevalence of autism spectrum disorders in preschool children in Guangzhou mainstream kindergartens is similar to that of foreign reports. The teacher nomination strategy shows good objectivity, high accuracy and high efficiency in screening stage, and could be used widely.关键词
孤独症谱系障碍/患病率/广州市幼儿园/学龄前儿童/横断面研究Key words
autism spectrum disorders/ prevalence/ kindergartens in Guangzhou/ preschool children/ crosssectional studies分类
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王馨,胡敏,李诗韵,修丽娟,郭嘉,梁华妮,宁静,程舒媛,樊越波,杨文翰,金宇,静进,黄旭,李秀红,魏薇,暴芃,王惠..广州市幼儿园儿童孤独症谱系障碍患病率和相关因素[J].中国心理卫生杂志,2011,25(6):401-408,8.
