癌症（英文版）2011，Vol.30Issue(5)：336-343,8.
Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma
Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma
摘要
Abstract
Recent evidence suggests that the chemokine axis of CXC chemokine ligand-12 and its receptor CXC chemokine receptor-4 (CXCL12/CXCR4) is highly expressed in gynecological tumors and the axis of CXC chemokine ligand-16 and CXC chemokine receptor-6 (CXCL16/CXCR6) is overexpressed in inflammation-associated tumors. This study aimed to determine the relationship between CXCL12/CXCR4, CXCL16/CXCR6 and ovadan carcinoma's clinicopathologic features and prognosis. Accordingly, the expression of these proteins in ovarian tissues was detected by tissue microarray and immunohistochemistry. The expressions of CXCL12/CXCR4 and CXCL16/CXCR6 were significantly higher in epithelial ovadan carcinomas than in normal epithelial ovadan tissues or benign epithelial ovadan tumors. The expression of chemokines CXCL12 and CXCL16 were positively correlated with their receptors CXCR4 and CXCR6 in ovarian carcinoma, respectively (r = 0.300, P ＜ 0.05; r = 0.395, P ＜ 0.05). Moreover, the expression of CXCL12 was related to the occurrence of ascites (X2 ＝ 4.76, P ＜ 0.05), the expression of CXCR4 was significantly related to lymph node metastasis (X2 ＝ 4.37, P ＜ 0.05), the expression of CXCR6 was significantly related to lymph node metastasis (X2 = 7.43, P ＜ 0.05) and histological type (X2 = 33.48, P ＜ 0.05). ln univariate analysis, the expression of CXCR4 and CXCL16 significantly correlated with reduced median survival (X2 = 4.67, P ＜ 0.05; X2 = 4.48, P ＜ 0.05). Therefore, we conclude that the chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 may play important roles in the growth, proliferation, invasion, and metastasis of epithelial ovarian carcinoma.关键词
Epithelial ovarian carcinoma/ chemokine/ CXCL12/ CXCL16Key words
Epithelial ovarian carcinoma/ chemokine/ CXCL12/ CXCL16引用本文复制引用
Li Guo,Zhu-Mei Cui,Jia Zhang,Yu Huang..Chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 correlate with lymph node metastasis in epithelial ovarian carcinoma [J].癌症（英文版）,2011,30(5):336-343,8.基金项目
This work was supported by grants from National Natural Science Foundation for Young Scholars of China (No.30700763) （No.30700763）
Promotive Research Foundation for Excellent Young and Middle-aged Scientists of Shandong (No.BS2009SW002). （No.BS2009SW002）
